Selective serotonin reuptake inhibitors as a novel class of immunosuppressants

Selective serotonin reuptake inhibitors as a novel class of immunosuppressants.

In the past decades, selective serotonin reuptake inhibitors (SSRIs) have been shown to exert several immunological effects, such as reduced lymphocyte proliferation, alteration of cytokine secretion and induction of apoptosis. Based on these effects, SSRIs were proposed as drugs for the treatment of autoimmune pathologies and graft-versus-host disease. This review summarizes preclinical and cl...

Selective Serotonin Reuptake Inhibitors: A Class Review

OVERVIEW Many changes and therapeutic advances have occurred in the treatment of depression in recent years, most notably the availability of the selective serotonin reuptake inhibitor (SSRI) class of agents, followed by the introduction of escitalopram oxalate (LexaproTM, Forest), the first agent in what is known as the “second generation” of SSRIs. However, because of the higher acquisition c...

Selective Serotonin Reuptake Inhibitors

It has long been postulated that a deficiency in CNS serotonergic activity is the cause of, or a predisposing factor for, depression. [1] However, the evidence for this association is largely circumstantial and it certainly does not represent an adequate and full model for depression, probably due to there being multiple aetiological factors. [2] Some pharmacological trial data also cast doubt ...

Selective serotonin reuptake inhibitors.

Myoclonus as a Single Side Effect of Combination of Selective Serotonin Reuptake Inhibitors (SSRIs) and Clomipramine: Three Case Reports

   Selective Serotonin Reuptake Inhibitors (SSRIs) are the most popular psychiatric medications that are approved for several neuropsychiatric conditions such as depression and obsessive-compulsive disorder (OCD). On the other hand, clomipramine is a tricyclic anti-depressant which is the only approved medication, among this class, to treat OCD due to its substantial effects on serotonergic sys...